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One recommended approach is to choose a difference that would be clinically important one large enough to change treatment policy. In the Venus II trial of the effect of larval therapy on healing of venous leg ulcers, researchers determined the clinically important difference in healing time by asking patients what mattered to them.2 This is unusual, however, and more often the difference sought is the researchers’ idea. An alternative is to say https://www.buypriligyaustralia.nu how big a difference the researchers think that the treatment will produce. Researchers are often wildly optimistic, and funding committees often shake their heads over the implausibility of treatment changes reducing mortality by 50% or more.

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